Mon 11:43 am +01:00,
13 Nov 2023 3
posted by Tapestry
Landray is a very busy man, too busy, apparently, to look up the proper dose of a drug he gave to over 1500 subjects, who were randomized to the treatment and had no say in the matter.
We know that in Brazil, both a high CQ dose and a low CQ dose were trialed, and by April 17 the high dose arm was stopped prematurely due to an excess of deaths, with 39% mortality (16 deaths in 41 subjects). The mean age in the high dose group was 54.7. The high dose arm used 600 mg CQ twice daily for ten days, with cumulative dose of 12 grams. EKG changes typical of toxicity were seen in 25% of high dose subjects. The low dose trial continues in Brazil.
How is the drug hydroxychloroquine normally used? For chronic daily use in systemic lupus erythematosus, rheumatoid arthritis or Lyme disease, patients receive between 200 and 400 mg daily, or a maximum of 5 mg/kg. In acute Q fever, 600 mg daily may be given at the start of treatment. For acute attacks of malaria, 1,500–2,000 mg may be given over 3 days. Professor Didier Raoult’s group in Marseille used 600 mg daily for up to ten days in 1061 Covid-19 patients, and reported 8 deaths, a mortality rate of 0.75%, all over 74 years of age. The mortality rate reported by Landray and Horby in the Recovery trial is 34 times higher.
We know from WHO’s March 13 Informal consultation on the potential role of chloroquine that the Gates Foundation had been studying the drug’s complex pharmacokinetics, and of the 25 participants at this meeting, 5 were from the Gates Foundation.
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#Brazil